Dictyostelium discoideum: a model system for cell-cell interactions in development.
نویسنده
چکیده
The cellular slime mold Dictyostelium discoideum undergoes a transition from single-celled amoebae to a multicellular organism as a natural part of its life cycle. A method of cell-cell signaling that controls chemotaxis, morphogenesis, and gene expression has developed in this organism, and a detailed understanding of this signaling system provides clues to mechanisms of intercellular communication in the development of metazoans.
منابع مشابه
Choice of partners: sexual cell interactions in Dictyostelium discoideum.
Recognition of mating partners is of central importance in the sexual processes. In consideration that the most important function of sexuality is to shuffle genetic materials to generate wider variation of characters, mating among different genetic backgrounds is preferable. Wild isolates of cellular slime mold Dictyostelium discoideum are predominantly heterothallic, but homothallic ones also...
متن کاملInter-relation of cell adhesion and differentiation in Dictyostelium discoideum.
During the development of Dictyostelium discoideum single cells aggregate to form a multicellular organism. The change from the single cell state to multicellularity is mediated by chemotactic cell movement and intercellular adhesion. Dictyostelium represents a side branch in the evolution of multicellular organization in eukaryotes. Therefore, the general importance of any work done in Dictyos...
متن کاملDissection of Francisella-Host Cell Interactions in Dictyostelium discoideum.
Francisella bacteria cause severe disease in both vertebrates and invertebrates and include one of the most infectious human pathogens. Mammalian cell lines have mainly been used to study the mechanisms by which Francisella manipulates its host to replicate within a large variety of hosts and cell types, including macrophages. Here, we describe the establishment of a genetically and biochemical...
متن کاملDevelopmental decisions in Dictyostelium discoideum.
Dictyostelium discoideum is an excellent system in which to study developmental decisions. Synchronous development is triggered by starvation and rapidly generates a limited number of cell types. Genetic and image analyses have revealed the elegant intricacies associated with this simple development system. Key signaling pathways identified as regulating cell fate decisions are likely to be con...
متن کاملDictyostelium discoideum: A Model System to Study Autophagy Mediated Life Extension
Autophagy is a major catabolic process in eukaryotes that help degrade and recycle macromolecules and organelles. Recent evidences suggest autophagy to mediate cytoprotection and also help increase longevity. It acts as a central regulatory mechanism for aging/longevity in diverse eukaryotic species. In the present study we have exploited the lower eukaryotic model organism, Dictyostelium disco...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Science
دوره 245 4922 شماره
صفحات -
تاریخ انتشار 1989